The SLIM LIVER Study

FOR PEOPLE WITH HIV WITH NON-ALCOHOLIC FATTY LIVER DISEASE

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The UW AIDS Clinical Trials Unit is looking for people living with HIV 18 and older who have been taking HIV medicines for at least 1 year and undetectable for at least 24 weeks who have been diagnosed with non-alcoholic fatty liver disease by imaging at a pre-entry visit.

ABOUT THIS STUDY

 

It is estimated that 30-40% of adults living with HIV have non-alcoholic fatty liver disease (NAFLD). NAFLD is the buildup of extra fat in the liver cells that is not caused by alcohol.

Treating NAFLD may have far-reaching benefits, including reduction of insulin resistance and prevention or treatment of cardiovascular disease, which is often associated with NAFLD.

The SLIM LIVER Study will investigate the effects of a drug called semaglutide to see if it will reduce liver fat in people with HIV and if it has any effect on factors that are associated with the development of fatty liver disease.

Semaglutide will be given once a week as a self-injection for 24 weeks. Participants will be followed for an additional 24 weeks after stopping the study drug.

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REQUIREMENTS

  • All people with HIV

  • Ages 18 and older

  •  No change in HIV medicine in 24 weeks

  •  Undetectable HIV viral load for 24 weeks

  •  Have fatty liver disease (diagnosed by imaging at a pre-entry visit)

  •  CD4 T cell count of at least 200 

  •  No diabetes

  •  No heavy drinking (alcoholic drinks)

  •  No current hepatitis B or C

PLUS:

  • MEDICAL HISTORY

  •  PHYSICAL EXAMS

  •  BLOOD DRAWS

  •  MRI OF YOUR LIVER

  •  QUESTIONNAIRES

  •  3-DAY FOOD DIARY

  •  STOOL COLLECTION

 

$20 for each visit starting at the Screening Visit

$60 for the MRI

$20 for Stool Collection

Exams, tests and the study medicines are provided AT NO COST to you.

INTERESTED?

Please contact our Research Nurse at 206-773-7129 (call or text)

for more information or to schedule a screening appointment.

Treating Non-Alcoholic Fatty Liver Disease
in People Living with HIV

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